Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles
Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles
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DOI：
10.1007/978-1-61779-052-2_12
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Park, Kinam
中科院分区：
文献类型：
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作者：
Acharya, Ghanashyam;McDermott, Matthew;Park, Kinam
具有均匀尺寸分布和预定义形状的纳米/微粒药物递送系统对于理解这些系统的几何形状和尺寸对血液循环时间和细胞摄取的影响非常重要。我们提出了一种使用水溶性水凝胶模板来制造尺寸范围为 200 nm 至 50 μm 的均质、形状特异性聚合物/药物结构的通用方法。这种水凝胶模板策略温和、廉价且易于扩展，可用于多功能药物输送载体的制造。
Nano/microparticulate drug delivery systems with homogeneous size distribution and predefined shape are important in understanding the influence of the geometry and dimensions of these systems on blood circulation times and cellular uptake. We present a general method using water dissolvable hydrogel templates for the fabrication of homogeneous, shape-specific polymer/drug constructs in the size range of 200 nm to 50 mu m. This hydrogel template strategy is mild, inexpensive, and readily scalable for the fabrication of multifunctional drug delivery vehicles.