Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus
Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus
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DOI：
10.1093/jac/dki052
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发表时间：
2005-04-01
影响因子：
5.2
通讯作者：
Collignon, P
中科院分区：
文献类型：
--
作者：
Fernandes, CJ;Fernandes, LA;Collignon, P
目的：为了评估头孢西丁的有用性时，作为一个替代标记物用于检测methicillin resistance.Patients和方法：八百七十一株金黄色葡萄球菌，收集从八个三级转诊中心服务于不同的社会经济群体，包括在研究中使用NCCLS光盘扩散和琼脂稀释法。以头孢西丁和NCCLS纸片扩散法为标准，识别甲氧西林耐药的敏感性和特异性均为100%。用琼脂稀释法对菌株进行检测时，得到了类似的结果。头孢西丁对甲氧西林敏感菌株的MIC为
Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance.Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods.Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were