let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation.
let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation.
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DOI：
10.3390/biomedicines9060606
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发表时间：
2021-05-26
期刊：
影响因子：
4.7
通讯作者：
Rom S
中科院分区：
文献类型：
--
作者：
Bernstein DL;Jiang X;Rom S
let-7 家族是最早发现的 microRNA 之一。最近的研究表明它在许多系统中高度表达，包括大脑和心血管系统。许多研究表明let-7成员的异常表达与心血管疾病有关，例如中风、心肌梗塞(MI)、心脏纤维化和动脉粥样硬化以及与这些疾病相关的炎症。此外，let-7 microRNA 参与心血管系统中胚胎干细胞的发育和分化。许多基因以及许多let-7’调节因子已被确定为let-7的靶基因。需要进一步的研究来确定let-7在心血管疾病和炎症过程中的基因靶标和信号通路。大部分 let-7' 调节蛋白在发育、增殖、分化和癌症方面已得到充分研究，但它们在炎症、心血管疾病和/或中风中的作用尚不清楚。关于 let-7 调控的进一步了解对于治疗进展至关重要。本文重点介绍let-7的作用及其在脑血管疾病和相关炎症中的调节作用的研究进展。
The let-7 family is among the first microRNAs found. Recent investigations have indicated that it is highly expressed in many systems, including cerebral and cardiovascular systems. Numerous studies have implicated the aberrant expression of let-7 members in cardiovascular diseases, such as stroke, myocardial infarction (MI), cardiac fibrosis, and atherosclerosis as well as in the inflammation related to these diseases. Furthermore, the let-7 microRNAs are involved in development and differentiation of embryonic stem cells in the cardiovascular system. Numerous genes have been identified as target genes of let-7, as well as a number of the let-7’ regulators. Further studies are necessary to identify the gene targets and signaling pathways of let-7 in cardiovascular diseases and inflammatory processes. The bulk of the let-7’ regulatory proteins are well studied in development, proliferation, differentiation, and cancer, but their roles in inflammation, cardiovascular diseases, and/or stroke are not well understood. Further knowledge on the regulation of let-7 is crucial for therapeutic advances. This review focuses on research progress regarding the roles of let-7 and their regulation in cerebral and cardiovascular diseases and associated inflammation.
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