Can bacterial type III effectors mediate pathogen-plant-microbiota ternary interactions?
Can bacterial type III effectors mediate pathogen-plant-microbiota ternary interactions?
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DOI：
10.1111/pce.14185
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发表时间：
2021-09
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通讯作者：
Xiaoli Liu;Jun Cai;Xiaoxu Li;F. Yu;Dousheng Wu
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作者：
Xiaoli Liu;Jun Cai;Xiaoxu Li;F. Yu;Dousheng Wu
革兰氏阴性细菌病原体通过其三型分泌系统将效应蛋白注入植物细胞，以操控细胞过程并促进感染。大多数三型效应蛋白的分子功能是抑制植物免疫。一些效应蛋白还会干扰宿主的其他细胞通路，包括激素信号传导、营养代谢、基因表达和蛋白质降解。截至目前，三型效应蛋白的致病功能仅在细菌 - 植物二元相互作用的背景下进行研究。然而，在自然条件下，感染部位的微生物组成比单一病原体更为复杂。我们推测，三型效应蛋白在细菌 - 植物 - 微生物群三元相互作用中发挥着重要作用，并间接塑造出有利于病原体的微生物群。初步数据支持了这一假设，即来自青枯雷尔氏菌的一种效应蛋白可操控宿主多胺，且可能抑制微生物竞争者。未来的研究将在三型效应蛋白的生物学功能方面取得概念性进展。本文受版权保护，保留所有权利。
Gram-negative bacterial pathogens inject effector proteins into plant cells via their type III secretion system to manipulate cellular processes and promote infection. The molecular function of most type III effectors is the suppression of plant immunity. Some effectors also interfere with other host cellular pathways including hormone signaling, nutrient metabolism, gene expression and protein degradation. As of yet, the virulence functions of type III effectors are exclusively studied in the context of bacteria-plant binary interactions. However, the microbial composition is more complex than the sole pathogen at the infection site under natural conditions. We speculate that type III effectors play an important role in bacteria-plant-microbiota ternary interactions and indirectly shape a microbiota benefiting the pathogen. This hypothesis is supported by preliminary data that an effector from Ralstonia solanacearum manipulates host polyamine and possibly inhibits microbial competitors. Future research will provide conceptual advance on the biological functions of type III effectors. This article is protected by copyright. All rights reserved.