A role of Ultrabithorax in morphological differences between Drosophila species
A role of Ultrabithorax in morphological differences between Drosophila species
复制标题
DOI：
10.1038/24863
复制
发表时间：
1998-12-03
期刊：
影响因子：
64.8
通讯作者：
Stern, DL
中科院分区：
文献类型：
--
作者：
Stern, DL
人们对形态进化背后的机制知之甚少(1,2)。相关性较远的类群有时会表现出形态差异与基因表达模式之间的相关性(3-8)，但此类比较无法确定机制如何进化以产生不同的形态。要回答这些问题，需要解决密切相关物种内部和之间发育进化的本质。在这里，我展示了 Hox 基因 Ultrabithorax 的详细调控如何在黑腹果蝇的第二条腿的股骨后部形成毛状体，并且 Ultrabithorax 的进化导致了密切相关的物种之间这一特征的分歧。Ultrabithorax 的顺式调控区域，而不是蛋白质本身，似乎已经进化。这项研究提供了实验证据，证明顺式调控进化是保守蛋白促进形态多样性的一种方式(1)。
The mechanisms underlying the evolution of morphology are poorly understood(1,2). Distantly related taxa sometimes exhibit correlations between morphological differences and patterns of gene expression(3-8), but such comparisons cannot establish how mechanisms evolve to generate diverse morphologies. Answers to these questions require resolution of the nature of developmental evolution within and between closely related species. Here I show how the detailed regulation of the Hox gene Ultrabithorax patterns trichomes on the posterior femur of the second leg in Drosophila melanogaster, and that evolution of Ultrabithorax has contributed to divergence of this feature among closely related species, The cis-regulatory regions of Ultrabithorax, and not the protein itself, appear to have evolved. This study provides experimental evidence that cis-regulatory evolution is one way in which conserved proteins have promoted morphological diversity(1).