Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence.
Metabolic Complications and Glucose Metabolism in HIV Infection: A Review of the Evidence.
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DOI：
10.1007/s11904-016-0330-z
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发表时间：
2016-10
影响因子：
4.6
通讯作者：
Overton ET
中科院分区：
文献类型：
--
作者：
Willig AL;Overton ET
HIV 感染和抗逆转录病毒治疗 (ART) 的使用与葡萄糖和脂质代谢的扰动有关。糖尿病、心血管疾病和肥胖症发病率的增加凸显了早期识别和治疗代谢功能障碍的必要性。较新的 ART 疗法对细胞功能和代谢的毒性较小，但未能完全消除 HIV 感染引起的代谢功能障碍。其他因素，包括病毒与宿主的相互作用、饮食、体力活动、非抗逆转录病毒药物和衰老，可能会进一步增加艾滋病毒感染者的代谢疾病风险。我们总结了有关 HIV 感染、ART 以及药物或生活方式处方对代谢功能影响的最新文献。
HIV infection and antiretroviral therapy (ART) use are associated with perturbations in glucose and lipid metabolism. Increasing incidence of diabetes, cardiovascular disease, and obesity highlights the need for early identification and treatment of metabolic dysfunction. Newer ART regimens are less toxic for cellular function and metabolism but have failed to completely eliminate metabolic dysfunction with HIV infection. Additional factors, including viral-host interactions, diet, physical activity, non-ART medications, and aging may further contribute to metabolic disease risk in the HIV setting. We summarize the recent literature regarding the impact on metabolic function of HIV infection, ART, and pharmaceutical or lifestyle prescriptions.