Rapid evolution of expression and regulatory divergences after yeast gene duplication
Rapid evolution of expression and regulatory divergences after yeast gene duplication
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DOI：
10.1073/pnas.0409186102
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发表时间：
2005-01-18
影响因子：
11.1
通讯作者：
Huang, W
中科院分区：
文献类型：
--
作者：
Gu, X;Zhang, ZQ;Huang, W
虽然基因复制被广泛认为是遗传新奇的主要来源，但对复制基因的表达或调控网络如何进化仍然知之甚少。在这篇文章中，我们提出了一个加性的重复基因之间的表达距离，使基因重复后的表达分歧的进化速度可以估计通过重复基因组分析。我们已经分析了酵母基因组序列、微阵列和转录调控网络，显示基因复制后表达和调控网络进化的初始速率增加> 10倍，但蛋白质序列在早期阶段的速率仅增加约20%。基于酵母复制基因的估计年龄分布，我们粗略估计基因复制后不久的表达分歧的初始速率为每年2.9 × 10（-9），而非常古老的基因复制的基线速率为每年0.14 × 10（-9）。相对表达率测试表明，重复基因的表达倾向于不对称地进化，即一个拷贝的表达迅速进化，而另一个在很大程度上保持了祖先的表达谱。我们的研究强调了基因/基因组复制后早期快速进化对不断增加酵母调控网络复杂性的关键作用。
Although gene duplication is widely believed to be the major source of genetic novelty, how the expression or regulatory network of duplicate genes evolves remains poorly understood. In this article, we propose an additive expression distance between duplicate genes, so that the evolutionary rate of expression divergence after gene duplication can be estimated through phylogenomic analysis. We have analyzed yeast genome sequences, microarrays, and transcriptional regulatory networks, showing a > 10-fold increase in the initial rate for both expression and regulatory network evolution after gene duplication but only an approximate to 20% rate increase in the early stage for protein sequences. Based on the estimated age distribution of yeast duplicate genes, we roughly estimate that the initial rate of expression divergence shortly after gene duplication is 2.9 x 10(-9) per year, whereas the baseline rate for very ancient gene duplication is 0.14 x 10(-9) per year. Relative expression rate tests suggest that the expression of duplicate genes tends to evolve asymmetrically, that is, the expression of one copy evolves rapidly, whereas the other one largely maintains the ancestral expression profile. Our study highlights the crucial role of early rapid evolution after gene/genome duplication for continuously increasing the complexity of the yeast regulatory network.