[Effect of orally administered chondrosine on uptake of 35S sulfate into rat cartilage].
[Effect of orally administered chondrosine on uptake of 35S sulfate into rat cartilage].
复制标题
[口服软骨素对大鼠软骨摄取35S硫酸盐的影响]。
DOI：
10.1248/yakushi.126.297
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
T. Toida
中科院分区：
文献类型：
--
作者：
S. Kusano;N. Igarashi;Shinobu Sakai;T. Toida
硫酸软骨素广泛存在于动物组织中，可能在不同类型的代谢反应以及保护关节、血管内壁、皮肤、骨骼等方面发挥重要作用。在软骨中，糖胺聚糖具有保护作用，特别是硫酸软骨素稳定结缔组织的纤维和细胞成分，同时对关节膜起润滑和保护作用。最近，硫酸软骨素已被用作治疗骨关节炎等关节疾病的营养食品，尽管硫酸软骨素等酸性和大分子物质可能无法通过肠道等消化器官吸收。在本研究中，我们研究了口服鲨鱼硫酸软骨素对大鼠软骨摄取无机(35)S硫酸盐的影响，发现与完整的硫酸软骨素相比，鲨鱼硫酸软骨素促进了(35)S硫酸盐进入软骨。
Chondroitin sulfate is widely distributed in animal tissues and possibly plays an important role in different types of metabolic reactions as well as protecting joints, the internal wall of blood vessels, skin, bone, etc. In cartilage, glycosaminoglycans have a protective function; in particular, chondroitin sulfate stabilizes fibrous and cellular elements of the connective tissue and, at the same time, lubricates and protects the membranes in joints. Recently, chondroitin sulfate has been used as a nutraceutical for the treatment of joint diseases such as osteoarthritis, although acidic and large molecules such as chondroitin sulfate might not be able to be absorbed through digestive apparatus such as the intestine. In this study, we investigated the effects of orally administered chondrosine derived from shark chondroitin sulfate on the uptake of inorganic (35)S sulfate into rat cartilage and found that chondrosine stimulates the incorporation of (35)S sulfate into cartilage compared with intact chondroitin sulfate.
T. Takebayashi、M. Iwamoto、A. Jikko、T. Matsumura、M. Enomoto-Iwamoto、F. Myokai、E. Koyama、T. Yamaai、K. Matsumoto、T. Nakamura、K. Kurisu 和 S. Noji
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--