ANCYLOSTOMA-CEYLANICUM IN THE HAMSTER - OBSERVATIONS ON THE HOST-PARASITE RELATIONSHIP DURING PRIMARY INFECTION
ANCYLOSTOMA-CEYLANICUM IN THE HAMSTER - OBSERVATIONS ON THE HOST-PARASITE RELATIONSHIP DURING PRIMARY INFECTION
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DOI：
10.1017/s003118200006220x
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发表时间：
1989-04-01
期刊：
影响因子：
2.4
通讯作者：
BEHNKE, JM
中科院分区：
文献类型：
--
作者：
GARSIDE, P;BEHNKE, JM
研究了自交系DSN和随机饲养的WO/GD和WO/CR仓鼠初次感染一种仓鼠适应菌株的过程。受感染的幼虫被口服，并开始在小肠中发育，而不进行组织迁移。在其他器官部位仅偶见幼虫。结果表明，发育中的幼虫在感染后3 ~ 4 d蜕皮，并在感染后9 ~ 11 d再次蜕皮至成虫前期。在感染后至少11周内，受感染仓鼠的蠕虫负荷保持稳定。无突然排出期，部分成虫可存活200天以上。总体而言，同时杀死的仓鼠群体中蠕虫的性别比例约为50%，尽管偶尔在单个动物中该比例偏向于一种性别。感染后2周，血包裹细胞体积（PCV）明显下降，并持续下降，直到感染后4-5周达到稳定点。PCV随后在整个观察期间保持低水平。被感染的仓鼠如果成群饲养，体重会减轻，但分开饲养则不会。体重减轻的动物组在感染后的11周内没有恢复到正常水平。这表明，这种钩虫感染模型在探索寄主-寄生虫关系方面有一定的空间，而犬类模型无法充分实现。
The course of primary infection with a hamster-adapted strain of Ancylostoma ceylanicum was studied in inbred DSN and randomly bred WO/GD and WO/CR hamsters. Infective larvae were administered orally and began to develop in the small intestine without embarking on a tissue migration. Only the occasional larva was detected in other organ sites. It was concluded that the developing larvae moulted on days 3-4 and again to the pre-adult stage about 9-11 days post-infection. Worm burdens in infected hamsters were stable for at least 11 weeks after infection. There was no sudden expulsive phase and some adult worms survived for over 200 days. Overall the sex ratio of worms in groups of hamsters killed concurrently was about 50% although occasionally the ratio was biased in favor of one sex in individual animals. The blood packed cell volume (PCV) was significantly depressed 2 weeks following infection and continued to decline until a point of stability was achieved 4-5 weeks post-infection. The PCV subsequently remained depressed throughout the period of observation. Infected hamsters lost weight if kept in groups, but not when housed in separate cages. Groups of animals which lost weight did not recover to normal values within 11 weeks of infection. It is suggested that this model of hookworm infection has scope for exploring aspects of the host-parasite relationship which the canine models cannot fulfill adequately.