Experience of the treatment with gemcitabine, docetaxel, and carboplatin (GDC) chemotherapy for patients with small-cell carcinoma of the prostate
Experience of the treatment with gemcitabine, docetaxel, and carboplatin (GDC) chemotherapy for patients with small-cell carcinoma of the prostate
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DOI：
10.1111/j.1442-2042.2006.01514.x
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发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
Arai, Yoichi
中科院分区：
文献类型：
--
作者：
Aoki, Hiroshi;Ishidoya, Shigeto;Arai, Yoichi
前列腺小细胞癌（SCCP）是一种罕见的实体。已经采取了许多治疗方式，但迄今为止还没有明确确定统一的治疗方法。我们采用吉西他滨、多西他赛和卡铂（GDC）方案联合化疗（治疗2例难治性SCCP患者）。病例1涉及一名53岁男性，在接受前列腺癌激素治疗（D1期）后被诊断出患有SCCP。GDC方案化疗6周期。最初，原发部位随着神经特异性烯醇化酶的下降和症状的缓解而减少;然而，发生了骨病，他在诊断出短链氯化石蜡后13个月死于癌症。病例2涉及一名69岁男性，主诉严重肛门疼痛。他接受了活检和一个巨大的前列腺肿瘤显示SCCP显示。他有盆腔淋巴结转移，但没有远处病变，并接受了四个周期的GDC化疗。他在接受后续放疗后出院，并保持稳定一段时间;然而，他死于可能的药物性肝炎。这是第一个报告的化疗与GDC对患者的SCCP。这一制度有可能强化本已取得的成果。
Small-cell carcinoma of the prostate (SCCP) is a rare entity. Many treatment modalities have been done, but thus far no uniform treatment has been clearly established. We carried out combination chemotherapy with gemcitabine, docetaxel, and carboplatin (GDC) regimen (for two patients with refractory SCCP. Case 1 involved a 53-year-old man diagnosed with SCCP after receiving hormone therapy for prostate cancer (stage D1). Six cycles of GDC chemotherapy was applied. Initially the primary site reduced according with a decline of neuro-specific enolase and with relief of the symptoms; however, bone disease occurred and he died of cancer 13 months after diagnosis of SCCP. Case 2 involved a 69-year-old man complaining of severe anal pain. He underwent a biopsy and a huge prostate tumor showing SCCP was showed. He had pelvic node metastases but no distant lesions, and received four cycles of GDC chemotherapy. He was discharged after receiving subsequent radiotherapy and remained stable for a while; however, he died of possible drug-induced hepatitis. This is the first report of chemotherapy with GDC against patients with SCCP. This regimen raised the possibility that it would intensify the outcome, which had been poorly achieved.