Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer
Clinical Significance of PRKCI Gene Expression in Cancerous Tissue in Patients With Gastric Cancer
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DOI：
10.21873/anticanres.13771
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发表时间：
2019-10-01
影响因子：
2
通讯作者：
Oshima, Takashi
中科院分区：
文献类型：
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作者：
Hashimoto, Itaru;Sakamaki, Kentaro;Oshima, Takashi
背景/目的：PRKCI基因编码蛋白激酶C i ota。蛋白激酶C1的过表达与胃癌和其他癌症患者的不良结局相关，但PRKC 1基因在胃癌中的作用尚未完全了解。因此，我们评估PRKCI基因表达在胃癌中的临床意义。材料与方法：检测398例胃癌患者癌组织及癌旁正常粘膜中PRKCI mRNA的表达水平。研究PRKCI基因表达与临床病理特征和预后的关系。结果：PRKCI高表达患者的总生存率低于低表达患者（p=0.016）。未观察到其他关系。发现PRKCI高表达是独立的预后因素（p=0.036，HR=1.44，95%CI =1.02-2.02）。结论：胃癌组织中PRKCI基因的表达可能是判断胃癌患者术后预后的一个有用指标。
Background/Aim: The PRKCI gene encodes Protein kinase C iota. The overexpression of protein kinase C iota is associated with poor outcomes in patients with gastric and other cancers, but the role of the PRKCI gene in gastric cancer is not fully understood. Thus, we evaluated the clinical significance of PRKCI gene expression in gastric cancer. Materials and Methods: PRKCI mRNA expression levels in cancerous tissues and adjacent normal mucosa from 398 patients with gastric cancer were measured. Relationships between PRKCI gene expression and clinicopathological characteristics and outcomes were examined. Results: Overall survival was lower in patients with a high expression of PRKCI than in those with low expression (p=0.016). No other relationships were observed. A high PRKCI expression was found to be an independent prognostic factor (p=0.036, HR=1.44, 95% CI=1.02-2.02). Conclusion: PRKCI gene expression in cancerous tissue might be a useful prognostic factor in patients with gastric cancer after gastrectomy.