Pain and analgesic response after third molar extraction and other postsurgical pain
Pain and analgesic response after third molar extraction and other postsurgical pain
复制标题
DOI：
10.1016/j.pain.2003.09.021
复制
发表时间：
2004-01-01
期刊：
影响因子：
7.4
通讯作者：
Moore, RA
中科院分区：
文献类型：
--
作者：
Barden, J;Edwards, JE;Moore, RA
进行急性疼痛研究的患者组（疼痛模型）是否对镇痛效果的估计有任何影响尚不确定。采用最近更新的4个系统综述的数据，研究阿司匹林600/650 mg、扑热息痛600/650 mg、扑热息痛1000 mg和布洛芬400 mg对疼痛模型的影响。疼痛缓解与时间曲线下的面积相当于至少50%的最大疼痛缓解超过6，它被用作结果测量。治疗组和安慰剂组的事件发生率、相对获益（RB）和需要治疗的数量（NNT）被用作荟萃分析的输出。在所有四种治疗中，安慰剂组的牙痛发生率均低于术后疼痛发生率。镇痛药、RB和NNT的事件发生率在不同的疼痛模型之间差异不大。在牙科和术后疼痛模型之间的止痛效果评估的系统差异仍未得到证实，总的来说，没有重大差异。(C) 2003国际疼痛研究协会。Elsevier B.V.版权所有。
There is uncertainty over whether the patient group in which acute pain studies are conducted (pain model) has any influence on the estimate of analgesic efficacy. Data from four recently updated systematic reviews of aspirin 600/650 mg, paracetamol 600/650 mg, paracetamol 1000 mg and ibuprofen 400 mg were used to investigate the influence of pain model. Area under the pain relief versus time curve equivalent to at least 50% maximum pain relief over 6 It was used as the outcome measure. Event rates with treatment and placebo, and relative benefit (RB) and number needed to treat (NNT) were used as outputs from the meta-analyses. The event rate with placebo was systematically statistically lower for dental than postsurgical pain for all four treatments. Event rates with analgesics, RB and NNT were infrequently different between the pain models. Systematic difference in the estimate of analgesic efficacy between dental and postsurgical pain models remains unproven, and, on balance, no major difference is likely. (C) 2003 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.