Current status of imaging in nonalcoholic fatty liver disease.
Current status of imaging in nonalcoholic fatty liver disease.
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DOI：
10.4254/wjh.v10.i8.530
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发表时间：
2018-08-27
影响因子：
2.4
通讯作者：
Samir AE
中科院分区：
文献类型：
--
作者：
Li Q;Dhyani M;Grajo JR;Sirlin C;Samir AE
非酒精性脂肪肝病 (NAFLD) 是最常见的弥漫性肝病，全球患病率为 20% 至 46%。 NAFLD可分为单纯性脂肪变性和非酒精性脂肪性肝炎。大多数单纯性脂肪变性病例是非进行性的，而非酒精性脂肪性肝炎可能会导致极少数人慢性肝损伤和进行性纤维化。 NAFLD 的有效风险分层和管理需要评估肝实质脂肪、纤维化和炎症。肝活检仍然是当前的黄金标准；然而，非侵入性成像方法正在迅速发展，在某些情况下可能取代活检。这些方法包括成熟的技术，例如传统超声检查、计算机断层扫描和磁共振成像，以及更新的成像技术，例如超声弹性成像、定量超声技术、磁共振弹性成像和基于磁共振的脂肪定量技术。本文的目的是回顾 NAFLD 风险分层和管理的影像学方法的现状，包括其诊断准确性、局限性和实际适用性。
Non-alcoholic fatty liver disease (NAFLD) is the most common diffuse liver disease, with a worldwide prevalence of 20% to 46%. NAFLD can be subdivided into simple steatosis and nonalcoholic steatohepatitis. Most cases of simple steatosis are non-progressive, whereas nonalcoholic steatohepatitis may result in chronic liver injury and progressive fibrosis in a significant minority. Effective risk stratification and management of NAFLD requires evaluation of hepatic parenchymal fat, fibrosis, and inflammation. Liver biopsy remains the current gold standard; however, non-invasive imaging methods are rapidly evolving and may replace biopsy in some circumstances. These methods include well-established techniques, such as conventional ultrasonography, computed tomography, and magnetic resonance imaging and newer imaging technologies, such as ultrasound elastography, quantitative ultrasound techniques, magnetic resonance elastography, and magnetic resonance-based fat quantitation techniques. The aim of this article is to review the current status of imaging methods for NAFLD risk stratification and management, including their diagnostic accuracy, limitations, and practical applicability.