Seroprevalence of pertussis among adults in China where whole cell vaccines have been used for 50 years
Seroprevalence of pertussis among adults in China where whole cell vaccines have been used for 50 years
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DOI：
10.1016/j.jinf.2016.04.004
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发表时间：
2016-07-01
影响因子：
28.2
通讯作者：
He, Qiushui
中科院分区：
文献类型：
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作者：
Chen, Zhiyun;Zhang, Jing;He, Qiushui
目的：方法：从2010年北京市20-39岁健康人群中随机抽取897份血清样本，分析百日咳在育龄期人群中的真实发病率。以纯化的百日咳毒素（Ptx）为包被抗原，用病毒/血清酶联免疫吸附试验（Virion/Serion ELISA）检测抗Ptx IgG抗体。平均浓度为13.76 IU/ml（95% CI，12.37-15.15）。46例（5.1%）受试者的抗Ptx IgG水平大于或等于40 IU/ml，表明百日咳感染，9例（1%）受试者的IgG抗体大于或等于100 IU/ml，表明一年内最近感染。20-29岁和30-39岁年龄组之间及性别之间无显著性差异。结论：20-39岁年龄组中约有5%的成人抗Ptx IgG抗体阳性，提示成人百日咳在我国较为常见。应该考虑对孕妇进行加强接种，以保护在这个国家太小而不能接种疫苗的婴儿。(C)2016年，英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To estimate the true incidence of pertussis in Chinese adults who are at a childbearing age.Methods: A total of 897 serum samples from healthy individuals aged 20-39 years were selected randomly from a large number of serum samples collected in 2010 in Beijing, China. Anti-pertussis toxin (Ptx) IgG antibodies were determined with the Virion/Serion ELISA kits using purified Ptx as a coating antigen.Results: Only 124 (13.8%) were found to have undetectable anti-Ptx IgG antibodies. The mean concentration was 13.76 IU/ml (95% CI, 12.37-15.15). Forty-six (5.1%) subjects had anti-Ptx IgG levels greater than or equal to 40 IU/ml, indicative of a pertussis infection, and nine (1%) had IgG antibodies greater than or equal to 100 IU/ml, indicative of a recent infection within a year. No significant differences were observed between age groups of 20-29 and 30-39 years, or between genders.Conclusions: Our study showed that about 5% of adults aged 20-39 years had positive anti-Ptx IgG antibodies, suggesting that adult pertussis is common in China. Giving a booster vaccination to pregnant women should possibly be considered in order to protect young infants who are too young to be vaccinated in this country. (C) 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.