Clinical characteristics of dermatomyosits/polymyositis associated interstitial lung disease according to the autoantibody
Clinical characteristics of dermatomyosits/polymyositis associated interstitial lung disease according to the autoantibody
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DOI：
10.2152/jmi.65.251
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发表时间：
2018-08-01
影响因子：
0.7
通讯作者：
Yamashiro, Shin
中科院分区：
文献类型：
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作者：
Kishaba, Tomoo;McGill, Rita;Yamashiro, Shin
背景：皮肌炎(DM)和多发性肌炎(PM)常与具有疾病特异性自身抗体的间质性肺病(ILD)有关。方法：根据自身抗体复习2000-01/2017-12 DM/PM相关ILD的病历。结果：52例患者中，30例抗体阴性，18例抗氨酰-tRNA合成酶(ARS)抗体，4例抗黑色素瘤分化相关基因(MDA)-5抗体。在胸部高分辨率CT上，抗mda-5抗体阳性患者的磨玻璃影、实变和肺尖实变范围更广(p=0.051，p=0.026，p=0.027)。在实验室检查结果中，GOT与CPK有很强的相关性(r=0.889，p
Background : Dermatomyositis (DM) and polymyositis (PM) often have association with interstitial lung disease (ILD) which have disease specific autoantibody. Methodology : We reviewed medical records of DM/PM associated ILD from January 2000 to December 2017 according to the autoantibody. Result : We identified 52 patients, of whom 30 were antibody negative, 18 had anti aminoacyl-tRNA synthetases (ARS) antibodies and 4 had anti melanoma differentiation-associated gene (MDA)-5 antibody. In high resolution computed tomography (HRCT) of the chest, area of ground glass opacity (GGO), consolidation, and lung tip consolidation were more extensive in anti MDA-5 antibody positive patients (p=0.051, p=0.026, and p=0.027, respectively). Among laboratory findings, GOT had strong correlations with CPK (r=0.889, p