Prostate cancer prevention trials in the USA
Prostate cancer prevention trials in the USA
复制标题
DOI：
10.1016/s0959-8049(00)00105-2
复制
发表时间：
2000-06-01
影响因子：
8.4
通讯作者：
Parnes, H
中科院分区：
文献类型：
--
作者：
Brawley, OW;Parnes, H
前列腺癌死亡率的国际差异很大。这种差异表明，这种疾病与环境有关，并鼓励人们寻找预防这种疾病的方法。一段时间内的雄激素刺激，可能是由于高脂肪饮食，被认为是前列腺癌的一个原因。这一假设的推论是，随着时间的推移，降低雄激素刺激将预防前列腺癌。通过非那雄胺等药物抑制5- α还原酶已被证明可以减少雄激素刺激或前列腺。一项临床试验正在使用非那雄胺来评估这一假设。流行病学和实验室研究也表明，摄入大量硒和维生素E的人患前列腺癌的风险较低。最近两项随机临床试验的偶然发现支持了这一点。目前正在设计一项评估这些化合物的研究。在前列腺癌的化学预防方面，其他有希望但不太发达的干预措施包括补充维生素D和改变饮食。(C) 2000, Elsevier Science Ltd.出版版权所有。
There is dramatic international variation in prostate cancer mortality rates. The variation suggests that the disease has an environmental cause and encourages the search for a way to prevent it. Androgenic stimulation over a period of time, perhaps due to a high fat diet, has been suggested as a cause of prostate cancer. The corollary to this hypothesis is that lowering androgenic stimulation over time will prevent prostate cancer. 5-Alpha-reductase inhibition through drugs like finasteride have been shown to decrease androgenic stimulation or the prostate. A clinical trial is underway using finasteride to assess this hypothesis. Epidemiological and laboratory studies also suggest that those with high selenium and vitamin E intake have a lower risk of prostate cancer. Recent serendipitous findings of two randomised clinical trials support this. A study to assess these compounds is currently being designed. Other promising but less developed interventions in the chemoprevention of prostate cancer include vitamin D supplementation and diet modification. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.