Histamine in two component system-mediated bacterial signaling
Histamine in two component system-mediated bacterial signaling
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DOI：
10.2741/3976
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Tiligada, Ekaterini
中科院分区：
文献类型：
--
作者：
Kyriakidis, Dimitrios A.;Theodorou, Marina C.;Tiligada, Ekaterini
组胺是哺乳动物中控制重要细胞过程的关键介质，而不仅仅是其在炎症中的决定性作用。最近的证据表明，在真核生物和原核生物的额外行动。除了在宿主防御细菌感染中的功能外，组胺还在微生物中激发可能有助于细菌-宿主相互作用的大量未定义的作用。细菌的增殖和适应是由复杂的信号转导网络，包括多功能的双组分系统（TCS），包括传感器组氨酸激酶和反应调节剂，并依赖于磷酸转移机制发挥其调节功能。AtoSC TCS调节大肠杆菌中的基本细胞过程，如短链脂肪酸代谢、聚（R）-3-羟基丁酸酯（cPHB）生物合成和趋化性。外源性组胺在AtoSC介导的cPHB生物合成和E.大肠杆菌趋化行为表明组胺在细菌生理学中的假定功能。这些数据提出了关于组胺作用在细菌-宿主共生、生态失调和致病性中的意义的问题，以及关于组胺受体靶向剂和特别是最近鉴定的免疫调节H-4受体的配体的治疗性给药后的可能后果的问题。
Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined actions in microorganisms that may contribute to bacteria-host interactions. Bacterial proliferation and adaptation are governed by sophisticated signal transduction networks, including the versatile two-component systems (TCSs) that comprise sensor histidine kinases and response regulators and rely on phosphotransfer mechanisms to exert their modulatory function. The AtoSC TCS regulates fundamental cellular processes such as short-chain fatty acid metabolism, poly-(R)-3-hydroxybutyrate (cPHB) biosynthesis and chemotaxis in Escherichia coli. The implication of exogenous histamine in the AtoSC-mediated cPHB biosynthesis and in E. coli chemotactic behavior is indicative of a putative function of histamine in bacterial physiology. The data raise questions on the significance of histamine actions in bacteria-host symbiosis, dysbiosis and pathogenicity as well as on the possible consequences upon therapeutic administration of histamine receptor-targeting agents and in particular ligands of the recently identified immunomodulatory H-4 receptor.