Large dose hyperpolarized water with dissolution-DNP at high magnetic field
Large dose hyperpolarized water with dissolution-DNP at high magnetic field
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DOI：
10.1016/j.jmr.2016.11.008
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发表时间：
2017-01-01
影响因子：
2.2
通讯作者：
Ardenkjaer-Larsen, Jan Henrik
中科院分区：
文献类型：
--
作者：
Lipso, Kasper Wigh;Bowen, Sean;Ardenkjaer-Larsen, Jan Henrik
我们展示了一种通过在强磁场下溶解动态核极化来制备超极化水的方法。用188g赫兹的调频微波辐射使质子在6.7T和1.1K下极化70%。在两相体系的溶解过程中，样品中97.2+/-0.7%的自由基被提取出来。获得了16+/-1mL5.0 MH-1的D2O溶液，在液体状态下极化为13.0+/-0.9%，与9.4T和293K的热平衡相比，增强因子为4000300，测得S的纵向弛豫时间常数为16+/-1。这种方法产生的超极化水的体积使大型动物的血管造影和灌注量测量以及用于研究质子交换和极化转移到其他原子核的核磁共振实验成为可能。(C)2016 Elsevier Inc.保留所有权利。
We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1 K to >70% with frequency modulated microwave irradiation at 188G Hz .97.2 +/- 0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16 +/- 1 mL of 5.0 M H-1 in D2O with a polarization of 13.0 +/- 0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000 300 compared to the thermal equilibrium at 9.4 T and 293 K. A longitudinal relaxation time constant of 16 +/- 1 s was measured.The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei. (C) 2016 Elsevier Inc. All rights reserved.