Novel Phenothiazinium Photosensitizers For Photodynamic Therapy
Novel Phenothiazinium Photosensitizers For Photodynamic Therapy
复制标题
用于光动力治疗的新型吩噻嗪光敏剂
DOI：
10.1117/12.960198
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发表时间：
1989
影响因子：
3.2
通讯作者：
A. Cincotta
中科院分区：
文献类型：
--
作者：
L. Cincotta;J. Foley;A. Cincotta
在苯并吩恶嗪与硫的氧原子replament导致相应的吩噻嗪ehromophorus的效果，这种变化，以及其他结构的改变，对光敏单线态氧形成分配系数，并在体外的光毒性。一个简短的讨论，关于如何结构的修改可以带来这些参数的变化。初步结果表明，一些吩噻嗪类化合物可能是光动力学治疗中有前途的光敏剂。
The replament of the oxygen atom in benzophenoxazines with sulfur leads to the corresponding phenothiazinium ehromophorus The effect that this change, as well as other structural alterations, has on photosensitized singlet oxygen formation partitioning coefficient, and in-vitro phototoxicity is presented. A brief discussion concerning how structural modifications can bring about changes in these parameters is also presented. Preliminary results suggest that some phenothiazines could be promising photosensitizers for photodynamic therapy.