Development of a noninvasive method to measure intravascular and intracardiac pressure differences using magnetic resonance imaging.
Development of a noninvasive method to measure intravascular and intracardiac pressure differences using magnetic resonance imaging.
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DOI：
10.2463/mrms.7.113
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Murase, Kenya
中科院分区：
文献类型：
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作者：
Nagao, Taisuke;Yoshida, Keita;Murase, Kenya
目的：我们开发了一种使用磁共振（MR）成像来测量血管内和心内压力差异的无创方法，并研究了该方法在脉动流模型和人体研究中使用的可行性。方法：我们在1.5T MR扫描仪上使用相衬MR成像测量了3个速度分量，使用纳维-斯托克斯方程中的速度数据来获得压力梯度，并直接积分平面内压力梯度来计算压力差。为了验证我们的方法，我们将我们的方法获得的压力差与动脉狭窄轴对称模型获得的理论值进行了比较。我们还估计了模拟各种血管病变的玻璃管体模以及正常志愿者的左心室和主动脉弓的压力差作为临床应用。结果：通过我们的方法获得的压力差与使用狭窄为 45% 的直管体模获得的理论值非常吻合，但当狭窄为 65% 时，我们观察到一些差异。在体模和人体研究中，我们清楚地观察到心动周期不同阶段特定位置的压力差变化。结论：该方法对于测量血管内和心脏内压力差似乎很有用。
PURPOSE: We developed a noninvasive method using magnetic resonance (MR) imaging to measure differences in intravascular and intracardiac pressure, and we investigated the feasibility of the method's use in a pulsatile flow phantom and human studies.METHODS: We measured 3 velocity components using phase contrast MR imaging on a 1.5T MR scanner, used velocity data in Navier-Stokes equations to obtain pressure gradients, and directly integrated the in-plane pressure gradients to calculate pressure differences. To validate our method, we compared the pressure differences obtained by our method with the theoretical values obtained from an axisymmetric model of arterial stenosis. We also estimated the pressure differences in glass-tube phantoms simulating various vascular pathologies and in the left ventricle and aortic arch of a normal volunteer as clinical application.RESULTS: The pressure differences obtained by our method agreed well with theoretical values obtained using the straight-tube phantom with stenosis of 45%, but we observed some differences when stenosis was 65%. We clearly observed variations in pressure differences at specific locations at various phases of a cardiac cycle in both phantom and human studies.CONCLUSION: This method appears useful for measuring intravascular and intracardiac pressure differences.