Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
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DOI：
10.1038/sj.leu.2404721
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发表时间：
2007-07-01
期刊：
影响因子：
11.4
通讯作者：
Leung, A. Y. H.
中科院分区：
文献类型：
--
作者：
Cheung, A. M. S.;Wan, T. S. K.;Leung, A. Y. H.
乙醛脱氢酶 (ALDH) 活性用于定义正常造血干细胞 (HSC)，但其与急性髓系白血病 (AML) 中的白血病干细胞 (LSC) 的联系目前尚不清楚。我们假设 AML 中的 ALDH 活性可能与 LSC 的存在相关。从 AML (n = 43)、急性淋巴细胞白血病 (ALL) (n = 8) 和正常病例 (n = 7) 中采集了 58 份骨髓 (BM) 样本。在 14 例 AML 病例中，鉴定出高 SSClo ALDH(br) 细胞群 (ALDH(+)AML)（中位数：14.89%，范围：5.65-48.01%），其中大多数 SSClo ALDHbr 细胞共表达 CD34(+)。在另外 29 个病例中，存在无法检测到的 (n = 23) 或罕见的 (
Aldehyde dehydrogenase (ALDH) activity is used to define normal hematopoietic stem cell (HSC), but its link to leukemic stem cells (LSC) in acute myeloid leukemia (AML) is currently unknown. We hypothesize that ALDH activity in AML might be correlated with the presence of LSC. Fifty-eight bone marrow (BM) samples were collected from AML (n = 43), acute lymphoblastic leukemia (ALL) (n = 8) and normal cases (n = 7). In 14 AML cases, a high SSClo ALDH(br) cell population was identified (ALDH(+)AML) (median: 14.89%, range: 5.65-48.01%), with the majority of the SSClo ALDHbr cells coexpressing CD34(+). In another 29 cases, there was undetectable (n = 23) or rare (