Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding
Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding
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DOI：
10.1016/j.physbeh.2008.11.016
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发表时间：
2009-03-02
影响因子：
2.9
通讯作者：
Bolanos-Jimenez, Francisco
中科院分区：
文献类型：
--
作者：
Orozco-Solis, Ricardo;de Souza, Sandra Lopes;Bolanos-Jimenez, Francisco
在妊娠期和/或哺乳期限制蛋白质或热量摄入会导致食欲过旺，并增加成年期肥胖、葡萄糖耐受不良和高血压的易感性。然而，早期营养限制影响进食的正常生理调节的机制以及摄食过多的代谢程序在多大程度上导致肥胖和胰岛素抵抗的长期风险仍有待确定。在此，研究了在整个妊娠期和哺乳期喂食对照（C）或低蛋白（LP）饮食的Sprague-Dawley大鼠后代的摄食时间模式和行为饱腹感序列。在它们出生后的前两个月期间，蛋白质限制的动物表现出以延迟饱腹感出现、膳食量增加和猫的潜伏期减少为特征的摄食过多。蛋白质限制的幼崽还表现出增食欲肽Agouti相关蛋白和神经肽Y的表达增强以及增食欲肽前阿黑皮素的下丘脑水平降低。在8个月时，LP大鼠仍然比对照组大鼠消耗更多的食物，但它们每天摄入与对照组后代相同的食物量，并表现出腹部脂肪增加，血清中甘油三酯和脂肪酸水平升高。这些观察结果表明，在年轻的LP大鼠中观察到的摄食过多是由于对进餐终止至关重要的负反馈信号的作用降低和启动和维持进食的正信号的功能增强。这些结果还表明，围产期营养不良方案肥胖通过一种机制独立于其对喂养行为的影响。(C)2008年爱思唯尔公司All rights reserved.
Protein or caloric restriction during gestation and/or suckling induces hyperphagia and increases the susceptibility to develop obesity, glucose intolerance and hypertension in adulthood. The mechanisms by which early nutrient restriction affects the normal physiological regulation of feeding as well as to what extent the metabolic programming of hyperphagia contributes to the long-term risk of obesity and insulin resistance remain, however, to be determined. Here the temporal pattern of food intake and the behavioural satiety sequence were investigated in the offspring of Sprague-Dawley rats fed a control (C) or a low-protein (LP) diet throughout pregnancy and lactation. During the first two months of their post-natal life, protein-restricted animals exhibited hyperphagia characterized by a delayed appearance of satiety, an increase in meal size and reduced latency to cat Protein-restricted pups also exhibited an enhanced expression of the orexigenic peptides Agouti-related protein and neuropeptide Y and decreased hypothalamic levels of the anorexigenic peptide pro-opiomelanocortin, At 8 months, LP rats still consumed larger meals than their control counterparts but they ingested daily the same amount of food as control offspring and exhibited enhanced abdominal fat and increased levels or triglycerides and fatty acids in serum. These observations indicate that the hyperphagia observed in young LP rats results from a decreased action of negative feedback signals critical to meal termination and an enhanced function of the positive signals that initiate and maintain eating. These results also suggest that perinatal malnutrition programmes obesity through a mechanism independent of its effects on feeding behaviour. (C) 2008 Elsevier Inc. All rights reserved.