Exposure of Nail Salon Workers to Phthalates, Di(2-ethylhexyl) Terephthalate, and Organophosphate Esters: A Pilot Study
Exposure of Nail Salon Workers to Phthalates, Di(2-ethylhexyl) Terephthalate, and Organophosphate Esters: A Pilot Study
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DOI：
10.1021/acs.est.9b02474
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发表时间：
2019-12-17
影响因子：
11.4
通讯作者：
Webster, Thomas F.
中科院分区：
文献类型：
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作者：
Craig, Jessica A.;Ceballos, Diana M.;Webster, Thomas F.
关于美甲师在美甲沙龙中暴露于半挥发性有机化合物（SVOCs）的情况，人们知之甚少。我们收集了2016-17年波士顿地区10名女性美甲技师的班前和班后尿液样本以及翻领和手腕上佩戴的硅胶腕带（SWB）。我们分析了样品中的邻苯二甲酸盐、邻苯二甲酸盐替代品和有机磷酸酯（OPEs）或其代谢物。对于SVOC代谢物，班后尿液浓度通常高于班前浓度;最大的变化是邻苯二甲酸酯替代物对苯二甲酸二（2-乙基己基）酯（DEHTP）的代谢物：对苯二甲酸单（2-乙基-5-羧基戊基）酯（MECPTP）从11.7 μ g/g肌酐增加到36.6 μ g/g肌酐，增加了两倍多。与2015-2016年国家健康和营养检查调查女性相比，我们的研究参与者轮班后尿液中的DEHTP生物标志物更高。尿MECPTP和另一种DEHTP代谢产物与SWBs上的DEHTP中度相关（r = 0.37-0.60），表明职业是暴露源。我们的研究结果表明，美甲技师在职业上暴露于某些邻苯二甲酸酯、邻苯二甲酸酯替代品和OPEs，其中DEHTP的代谢物在一个工作日内的增幅最大。几个这些SVOCs SWBs的检测表明，他们可以被用来作为一种工具，检查潜在的职业暴露于SVOCs美甲沙龙工人。
Relatively little is known about the exposure of nail technicians to semivolatile organic compounds (SVOCs) in nail salons. We collected preshift and postshift urine samples and silicone wrist bands (SWBs) worn on lapels and wrists from 10 female nail technicians in the Boston area in 2016-17. We analyzed samples for phthalates, phthalate alternatives, and organophosphate esters (OPEs) or their metabolites. Postshift urine concentrations were generally higher than preshift concentrations for SVOC metabolites; the greatest change was for a metabolite of the phthalate alternative di(2-ethylhexyl) terephthalate (DEHTP): mono(2-ethyl-5-carboxypentyl) terephthalate (MECPTP) more than tripled from 11.7 to 36.6 mu g/g creatinine. DEHTP biomarkers were higher in our study participants postshift urine compared to 2015-2016 National Health and Nutrition Examination Survey females. Urinary MECPTP and another DEHTP metabolite were moderately correlated (r = 0.37-0.60) with DEHTP on the SWBs, suggesting occupation as a source of exposure. Our results suggest that nail technicians are occupationally exposed to certain phthalates, phthalate alternatives, and OPEs, with metabolites of DEHTP showing the largest increase across a work day. The detection of several of these SVOCs on SWBs suggests that they can be used as a tool for examining potential occupational exposures to SVOCs among nail salon workers.