Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study
Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study
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DOI：
10.1007/s10654-017-0242-2
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发表时间：
2017-07-01
影响因子：
13.6
通讯作者：
Laukkanen, Jari Antero
中科院分区：
文献类型：
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作者：
Kunutsor, Setor Kwadzo;Whitehouse, Michael Richard;Laukkanen, Jari Antero
镁是一种必需的微量元素，在几个细胞过程中起着关键作用，是骨骼的主要成分;然而，它与主要骨折风险的关系尚不确定。我们的目的是调查基线血清镁浓度与骨折风险的关系。我们分析了库奥皮奥缺血性心脏病前瞻性队列研究中2245名42-61岁男性的数据，评估了基线时的血清镁测量值和饮食摄入量。评估了总事件（股骨、肱骨和前臂）和股骨骨折的风险比[95%置信区间（CI）]。在中位随访25.6年期间，共记录了123例骨折。血清镁与总骨折风险呈非线性相关。在年龄校正的考克斯回归分析中，比较镁浓度的下四分位数与上四分位数，总骨折的风险比（HR）（95% CI）为2.10（1.30-3.41），在校正几个已确定的风险因素后仍为1.99（1.23-3.24）。进一步调整肾功能、社会经济地位、总能量摄入和几种微量元素后，这种关联仍然一致1.80（1.10-2.94）。股骨骨折的相应调整HR分别为2.56（1.38-4.76）、2.43（1.30-4.53）和2.13（1.13-3.99）。没有证据表明膳食镁摄入量与任何骨折风险相关。在中年白人男性中，低血清镁与骨折风险增加密切相关。需要进一步的研究来评估血清镁在预防骨折中的潜在相关性。
Magnesium, which is an essential trace element that plays a key role in several cellular processes, is a major component of bone; however, its relationship with risk of major bone fractures is uncertain. We aimed to investigate the association of baseline serum magnesium concentrations with risk of incident fractures. We analyzed data on 2245 men aged 42-61 years in the Kuopio Ischemic Heart Disease prospective cohort study, with the assessment of serum magnesium measurements and dietary intakes made at baseline. Hazard ratios [95% confidence intervals (CI)] for incident total (femoral, humeral, and forearm) and femoral fractures were assessed. During a median follow-up of 25.6 years, 123 total fractures were recorded. Serum magnesium was non-linearly associated with risk of total fractures. In age-adjusted Cox regression analysis, the hazard ratio (HR) (95% CIs) for total fractures in a comparison of the bottom quartile versus top quartile of magnesium concentrations was 2.10 (1.30-3.41), which persisted on adjustment for several established risk factors 1.99 (1.23-3.24). The association remained consistent on further adjustment for renal function, socioeconomic status, total energy intake, and several trace elements 1.80 (1.10-2.94). The corresponding adjusted HRs for femoral fractures were 2.56 (1.38-4.76), 2.43 (1.30-4.53) and 2.13 (1.13-3.99) respectively. There was no evidence of an association of dietary magnesium intake with risk of any fractures. In middle-aged Caucasian men, low serum magnesium is strongly and independently associated with an increased risk of fractures. Further research is needed to assess the potential relevance of serum magnesium in the prevention of fractures.