A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein.
A glial-neuronal signaling pathway revealed by mutations in a neurexin-related protein.
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神经毒素相关蛋白突变揭示的神经胶质神经元信号通路。
DOI：
10.1126/science.283.5406.1343
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Ganetzky,B
中科院分区：
文献类型：
--
作者：
Yuan,LL;Ganetzky,B
在神经系统中，神经胶质细胞的数量远远超过神经元，但它们在决定神经活动中的作用的全部范围仍然未知。果蝇的 axoactin (axo) 基因被证明编码由神经胶质细胞分泌的神经毒素蛋白超家族的成员，随后定位于轴突束。轴突的无效突变引起温度敏感麻痹和相应的轴突传导阻断。因此，AXO 蛋白似乎是神经胶质神经元信号传导机制的一个组成部分，有助于确定目标轴突的膜电特性。
In the nervous system, glial cells greatly outnumber neurons but the full extent of their role in determining neural activity remains unknown. Here the axotactin (axo) gene ofDrosophilawas shown to encode a member of the neurexin protein superfamily secreted by glia and subsequently localized to axonal tracts. Null mutations ofaxocaused temperature-sensitive paralysis and a corresponding blockade of axonal conduction. Thus, the AXO protein appears to be a component of a glial-neuronal signaling mechanism that helps to determine the membrane electrical properties of target axons.