MODULATION OF CELL JUNCTIONS DURING DIFFERENTIATION OF THE CHICKEN OTOCYST SENSORY EPITHELIUM
MODULATION OF CELL JUNCTIONS DURING DIFFERENTIATION OF THE CHICKEN OTOCYST SENSORY EPITHELIUM
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DOI：
10.1016/0012-1606(79)90247-1
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发表时间：
1979-01-01
影响因子：
2.7
通讯作者：
GILULA, NB
中科院分区：
文献类型：
--
作者：
GINZBERG, RD;GILULA, NB
鸡胚性耳囊内感觉细胞和支持细胞的分化伴随着原有细胞间连接分布的改变。在该上皮神经支配之前，所有细胞之间存在紧密、缝隙和粘连连接。在上皮分化后，紧密连接和粘连连接的顶端带始终保持不变，而缝隙连接和桥粒仅存在于支持细胞之间。随着感觉细胞的分化，一些在神经支配前与同质上皮细胞相连的缝隙连接被移除，在分化的支持细胞之间形成了一个单独的非常大的缝隙连接群体。形态证据表明，两种可能的机制可能导致观察到的缝隙连接分布的变化：通过内化消除缝隙连接和通过聚集前体颗粒形成缝隙连接。连接调节、感觉和支持细胞的细胞学分化以及神经纤维的生长之间的时间相关性使得后一种事件可能是这种上皮细胞分化的发育线索。
The differentiation of sensory and support cells within the embryonic chick otocyst is accompanied by alterations in the distribution of preexisting intercellular junctions. Prior to innervation of this epithelium, tight, gap and adhering junctions exist between all cells. Upon differentiation of the epithelium, apical bands of tight and adhering junctions are maintained throughout while gap junctions and desmosomes are found only between support cells. Some of the gap junctions that join homogeneous epithelial cells prior to innervation are removed as sensory cells differentiate and a separate population of very large gap junctions is formed between differentiating support cells. Morphological evidence suggests 2 possible mechanisms which may be responsible for the observed changes in gap junctional distribution: removal of gap junctions by internalization and formation of gap junctions by aggregation of precursor particles. The temporal correlation between junctional modulation, cytological differentiation of sensory and support cells, and ingrowth of nerve fibers makes the latter event a likely developmental cue for differentiation of this epithelium.