Characterization of obstructive sleep apnea in patients with insomnia across gender and age
Characterization of obstructive sleep apnea in patients with insomnia across gender and age
复制标题
不同性别和年龄的失眠患者阻塞性睡眠呼吸暂停的特征
DOI：
10.1007/s11325-015-1121-2
复制
发表时间：
2015-05-01
影响因子：
2.5
通讯作者：
Tang, Xiangdong
中科院分区：
文献类型：
--
作者：
Li, Zhe;Li, Yun;Tang, Xiangdong
大量的临床观察研究表明，女性阻塞性睡眠呼吸暂停（OSA）患者比男性患者更易出现失眠症状。目前还没有研究表明，年龄和性别的影响，OSA和慢性失眠症之间的关系，在大量的patients with insomnia.MethodsWe收集了860例慢性失眠症患者的数据，包括两性和广泛的年龄范围（平均年龄43.0 ± 12.1（范围18-81）岁，409名男性）。所有参与者在睡眠医学center. ResultsOSA的患病率基于三个不同的呼吸暂停低通气指数（AHI）类别（事件/h >5，>15，和>30）分别为42.5%，21.8%，和8.3%，男性和19.1%，6.2%，和1.8%，女性。在<35岁、35~<45岁、45~<55岁和≥55岁的年龄范围内，55岁以下男性OSA患病率显著高于女性，但在≥55岁的受试者中则无显著差异。AHI是高血压的重要危险因素;高AHI组（>30）与低AHI组（<5）相比，高血压的优势比为3.68（95%置信区间[CI]，1. 47 - 9. 21），调整所有其他因素后。结论与一般人群研究中报道的性别差异相似，在55岁之前，男性的OSA患病率比女性高得多，但在55岁以上则没有。
ObjectivesA large number of clinical observational studies have suggested that women patients with obstructive sleep apnea (OSA) have a higher presence of insomnia symptoms compared to men with OSA. There is no study that has examined the effect of age and gender on the relationship between OSA and chronic insomnia in a large number of patients with insomnia.MethodsWe collected data on 860 patients with chronic insomnia and included both sexes and a wide range of ages (mean age 43.0 ± 12.1 (range 18–81) years, 409 men). All participants underwent overnight polysomnography (PSG) in a sleep medicine center.ResultsThe prevalence of OSA based on three different apnea-hypopnea index (AHI) categories (events/h >5, >15, and >30) were 42.5, 21.8, and 8.3 % in men and 19.1, 6.2, and 1.8 % in women, respectively. Across age ranges of <35, 35~<45, 45~<55, and ≥55 years, the prevalence of OSA was remarkably greater in men than in women up to 55 years of age, but not in subjects with ages ≥55 years. AHI was a significant risk factor for hypertension; the odds ratio of hypertension in patients with high AHI (>30) compared to patients in the lowest AHI category (<5) was 3.68 (95 % confidence interval [CI], 1.47–9.21), after adjusting for all other factors.ConclusionSimilar to the gender differences reported in general population studies, men had a much greater OSA prevalence than women prior to 55 years of age, but not at ages greater than 55 years.