Aspergillus nidulans septin AspB plays pre- and postmitotic roles in septum, branch, and conidiophore development.
Aspergillus nidulans septin AspB plays pre- and postmitotic roles in septum, branch, and conidiophore development.
复制标题
构巢曲霉 septin AspB 在隔膜、分枝和分生孢子梗发育中发挥有丝分裂前和分裂后的作用。
DOI：
10.1091/mbc.01-06-0312
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发表时间：
2002
影响因子：
3.3
通讯作者：
Momany,Michelle
中科院分区：
文献类型：
--
作者：
Westfall,PatrickJ;Momany,Michelle
Members of the septin family of proteins act as organizational scaffolds in areas of cell division and new growth in a variety of organisms. Herein, we show that in the filamentous fungusAspergillus nidulans, the septin AspB is important for cellular division, branching, and conidiation both pre- and postmitotically. AspB localizes postmitotically to the septation site with an underlying polarity that is evident as cytokinesis progresses. This localization at the septation site is dependent on actin and occurs before the cross-wall is visible. AspB localizes premitotically as a ring at sites of branching and secondary germ tube emergence. It is the only known branch site marker. In addition, AspB is found at several stages during the development of the asexual reproductive structure, the conidiophore. It localizes transiently to the vesicle/metula and metula/phialide interfaces, and persistently to the phialide/conidiospore interface. A temperature-sensitive mutant of AspB shows phenotypic abnormalities, including irregular septa, high numbers of branches, and immature asexual reproductive structures.
