Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer® Foradile®
Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler—a Case Study on Aerolizer® Foradile®
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DOI：
10.1208/s12248-013-9458-6
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发表时间：
2013-02
期刊：
影响因子：
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通讯作者：
Q. Zhou;Z. Tong;P. Tang;M. Citterio;Runyu Yang;H. Chan
中科院分区：
文献类型：
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作者：
Q. Zhou;Z. Tong;P. Tang;M. Citterio;Runyu Yang;H. Chan
本研究的目的是研究Aerolizer®装置设计对载体干粉吸入剂制剂（Foradile®）雾化的影响。通过将进气口尺寸和吸嘴长度减少到原始尺寸的1/3或通过增加格栅空隙率来修改Aerolizer。在空气流速为30，60和100 L/min的多级液体撞击器上评估了粉末制剂的雾化。进行耦合CFD-DEM模拟以研究气流模式和颗粒碰撞。原始和1/3烟嘴长度器械之间的雾化行为无显著差异。当入口尺寸减小时，FPF总量和FPF排放量显着增加，并通过CFD分析中的空气速度和湍流增加解释了结果。当滤板空隙率增加时，总FPF和排出FPF无显著差异，但发现更多的药物存款在诱导端口，并在较小程度上，咬嘴。这得到了CFD-DEM分析的支持，CFD-DEM分析显示颗粒-器械碰撞主要发生在吸入器室中，交叉网格设计增加了吸嘴和吸入口上的颗粒-器械碰撞。发现Aerolizer®的进气口尺寸和网格结构对基于载体的粉末的雾化有显著影响。
The objective of this study is to investigate the effect of device design of the Aerolizer® on the aerosolization of a carrier-based dry powder inhaler formulation (Foradile®). The Aerolizer was modified by reducing the air inlet size and mouthpiece length to 1/3 of the original dimensions, or by increasing the grid voidage. Aerosolization of the powder formulation was assessed on a multi-stage liquid impinger at air flow rates of 30, 60, and 100 L/min. Coupled CFD-DEM simulations were performed to investigate the air flow pattern and particle impaction. There was no significant difference in the aerosolization behavior between the original and 1/3 mouthpiece length devices. Significant increases in FPF total and FPF emitted were demonstrated when the inlet size was reduced, and the results were explained by the increases in air velocity and turbulence from the CFD analysis. No significant differences were shown in FPF total and FPF emitted when the grid voidage was increased, but more drugs were found to deposit in induction port and to a lesser extent, the mouthpiece. This was supported by the CFD-DEM analysis which showed the particle–device collisions mainly occurred in the inhaler chamber, and the cross-grid design increased the particle–device collisions on both mouthpiece and induction port. The air inlet size and grid structure of the Aerolizer® were found to impact significantly on the aerosolization of the carrier-based powder.