Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.
Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.
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DOI：
10.1016/j.matbio.2016.01.001
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Trackman PC
中科院分区：
文献类型：
--
作者：
Trackman PC
综述了赖氨酰氧化酶家族酶蛋白在骨结构和功能中的生物学作用的进展。该蛋白质家族因催化胶原蛋白和弹性蛋白交联所需的最终反应而闻名。强调了这些蛋白质在祖细胞表型发育和血管生成中的新作用，并指出该家族在骨发育和体内平衡以及疾病中的酶促和非酶促作用。癌症领域对赖氨酰氧化酶家族的兴趣激增，凸显了需要在基本分子和细胞水平（包括矿化组织）的正常和异常结缔组织稳态中更好地了解该蛋白质家族的功能。
Advances in the understanding of the biological roles of the lysyl oxidase family of enzyme proteins in bone structure and function are reviewed. This family of proteins is well-known as catalyzing the final reaction required for cross-linking of collagens and elastin. Novel emerging roles for these proteins in the phenotypic development of progenitor cells and in angiogenesis are highlighted and which point to enzymatic and non-enzymatic roles for this family in bone development and homeostasis and in disease. The explosion of interest in the lysyl oxidase family in the cancer field highlights the need to have a better understanding of the functions of this protein family in normal and abnormal connective tissue homeostasis at fundamental molecular and cellular levels including in mineralized tissues.