VENTILATION-PERFUSION RATIO OBTAINED BY A NONINVASIVE FREQUENCY-RESPONSE TECHNIQUE
VENTILATION-PERFUSION RATIO OBTAINED BY A NONINVASIVE FREQUENCY-RESPONSE TECHNIQUE
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DOI：
10.1152/jappl.1976.41.3.419
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发表时间：
1976-01-01
影响因子：
3.3
通讯作者：
VANDIEREN, A
中科院分区：
文献类型：
--
作者：
ZWART, A;SEAGRAVE, RC;VANDIEREN, A
使用吸入氟烷浓度正弦变化的动物实验结果表明，呼气末浓度变化与吸入浓度变化的比率在Bode图中达到平台。借助摄取和分布模型，对结果的解释表明，平台水平由总体通气-灌注比决定。通过对输入频率、示踪剂和已知通气量的良好选择，可以无创地获得通气-灌注比和肺灌注。用20名志愿者测定平均通气-灌注比。在休息时，发现平均比率为0.87 ± 0.99。0.28（标准差）。在90 W的工作负荷下，发现平均比值为1.19 ± 0.01。0.19（标准差）。在2个人，重复性和CO2的影响进行了研究。在无额外CO2的静息状态下，通气-灌注比为0.71 ± 0.01。0.06在呼气末CO2水平为6%时，通气-灌注比增加了近2.5倍。在相同的工作负荷下，有和没有增加的呼气末CO2水平的计算灌注具有良好的重现性。
Results of animal experiments using sinusoidal changes in inspired halothane concentration showed that the ratio of variation in end-expired concentration to the variation in inspired concentration reached a plateau in the Bode diagram. With the help of an uptake and distribution model, the interpretation of the results showed that the level of the plateau is determined by the overall ventilation-perfusion ratio. With a good selection of input frequency, tracer agent, and known ventilation, the ventilation-perfusion ratio and the lung perfusion can be consequently obtained noninvasively. Mean ventilation-perfusion ratio was determined with 20 human volunteers. At rest a mean ratio was found of 0.87 .+-. 0.28 (SD). At a work load of 90 W a mean ratio was found of 1.19 .+-. 0.19 (SD). In 2 individuals, reproducibility and influence of CO2 was studied. At rest without additional CO2 the ventilation-perfusion ratio was 0.71 .+-. 0.06 (SD) obtained with a constant breathing rate of 10/min. At an end-expired CO2 level of 6%, the ventilation-perfusion ratio was increased almost 2.5 times. The calculated perfusion with and without increased end-expired CO2 levels under the same work load were well reproducible.