CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression.
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression.
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DOI：
10.1007/s10555-010-9256-x
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发表时间：
2010-12
影响因子：
9.2
通讯作者：
Wang, Jianhua
中科院分区：
文献类型：
--
作者：
Sun, Xueqing;Cheng, Guangcun;Hao, Mingang;Zheng, Jianghua;Zhou, Xiaoming;Zhang, Jian;Taichman, Russell S.;Pienta, Kenneth J.;Wang, Jianhua
趋化因子是一种与特异性G蛋白偶联的七跨膜受体（GPCR）结合的小的促炎性趋化因子，是细胞运输和粘附的主要调节因子。趋化因子CXCL 12 [也称为基质衍生因子-1（SDF-1）]是一种重要的α-趋化因子，主要与其同源受体CXCR 4结合，从而调节正常和恶性细胞的运输。多年来，人们一直认为CXCR 4是CXCL 12的唯一受体。然而，最近的研究表明，CXCL 12还与另一种称为CXCR 7的七跨膜受体结合。我们的团队和其他人已经确定了CXCR 4和CXCR 7在几种类型癌症中介导肿瘤转移的关键作用，除了作为肿瘤行为的生物标志物以及潜在的治疗靶点之外。在这里，我们回顾了目前的概念，CXCL 12/CXCR 4/CXCR 7轴激活的作用，调节肿瘤生长和转移扩散到器官表达高水平的CXCL 12发展继发性肿瘤的模式。我们还总结了最近的治疗方法，针对这些受体和/或其配体。
Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein coupled seven-span transmembrane receptors (GPCRs), are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [also called stromal-derived factor-1 (SDF-1)] is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the trafficking of normal and malignant cells. For many years it was believed that CXCR4 was the only receptor for CXCL12. Yet recent work has demonstrated that CXCL12 also binds to another seven-transmembrane span receptor called CXCR7. Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Here we review the current concepts regarding the role of CXCL12/CXCR4/CXCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CXCL12 to develop secondary tumors. We also summarize recent therapeutic approaches to target these receptors and/or their ligands.
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影响因子：
1.6
作者：
Billadeau, Daniel D.;Chatterjee, Subrha;Urrutia, Raul
通讯作者：
Urrutia, Raul
影响因子：
8
作者：
Burger, M;Glodek, A;Burger, JA
通讯作者：
Burger, JA
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
影响因子：
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作者：
Dambly-Chaudière C;Cubedo N;Ghysen A
通讯作者：
Ghysen A
影响因子：
7.8
作者：
Begley, L;Monteleon, C;Macoska, JA
通讯作者：
Macoska, JA