Ligustrazine monomer against cerebral ischemia/reperfusion injury.
Ligustrazine monomer against cerebral ischemia/reperfusion injury.
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DOI：
10.4103/1673-5374.156991
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发表时间：
2015-05
影响因子：
6.1
通讯作者：
Huang HY
中科院分区：
文献类型：
--
作者：
Gao HJ;Liu PF;Li PW;Huang ZY;Yu FB;Lei T;Chen Y;Cheng Y;Mu QC;Huang HY
川芎嗪（2，3，5，6-tetramethylpyrazine）是川芎的主要活性成分，广泛用于治疗缺血性脑血管病。川芎嗪治疗缺血性脑血管病的作用机制目前尚不清楚。本文综述了其对脑缺血再灌注损伤的保护作用、最佳给药时间窗和最有效的给药方式。本实验研究川芎嗪对内源性神经干细胞兴奋性氨基酸释放的抑制作用，以及对内源性神经干细胞迁移、分化和增殖的促进作用。我们还研究了它对血管生成的影响，以及它如何抑制脑缺血后的血栓形成、炎症反应和细胞凋亡。我们认为川芎嗪对脑缺血再灌注损伤有明显的保护作用。川芎嗪给药时间窗有限。川芎嗪的一系列衍生单体2-[（1，1-二甲基乙基）氧亚氨基]甲基]-3，5，6-三甲基吡嗪、CXC 137和CXC 195对脑缺血后的保护作用和时间窗均优于川芎嗪。
Ligustrazine (2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mechanism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administration, and the most effective mode of administration for clinical treatment of cerebral ischemia/reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine administration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC195 after cerebral ischemia were better than ligustrazine.