The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial
The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial
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DOI：
10.1515/cclm.2007.352
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发表时间：
2007-01-01
影响因子：
6.8
通讯作者：
Herrmann, Wolfgang
中科院分区：
文献类型：
--
作者：
Herrmann, Markus;Umanskaya, Natalia;Herrmann, Wolfgang
背景：高同型半胱氨酸血症是骨质疏松症的一个新的危险因素。本研究分析了同型半胱氨酸（HCY）降低治疗的效果在apootic individuals.Methods：骨质疏松症患者（n=47，55-82岁）进行治疗与2.5毫克叶酸，0.5毫克维生素B-12和25毫克维生素B，或安慰剂的组合。在基线和1年后测量腰椎和髋部的骨密度（BMD）。在0、4、8和12个月后测定尿-脱氧吡啶啉交联（DPD）和血浆抗酒石酸酸性磷酸酶（TRAP）、I型胶原C-末端交联（CTx）、I型前胶原N-末端肽（PINP）和骨钙素（OC）水平。（0 vs. 12个月：13.6 4.8 vs. 8.9 2.4 μ mol/L）。安慰剂治疗对HCY无影响（0个月与12个月：12.0 +/- 3.4与12.7 +/- 3.9 [μ mol/L]）。在整个研究过程中，两组的BIVID、TRAP、CTx、OC和PINP均未发生变化。维生素治疗使尿DPD降低了-13%（p15 μ Lmol/L，n =8），B族维生素治疗倾向于增加腰椎BMD，t评分为-2.7 ~-1.7，OC和PINP降低了约50%.Conclusions：B族维生素补充对骨转换或BMD没有一致的影响。然而，高同型半胱氨酸血症患者的情况可能有所不同。
Background: Hyperhomocysteinemia is a new risk factor for osteoporosis. This study analyzed the effect of a homocysteine (HCY)-lowering treatment in osteoporotic individuals.Methods: Osteoporotic subjects (n=47, 55-82 years) were treated with either a combination of 2.5 mg folate, 0.5 mg vitamin B-12 and 25 mg vitamin B, or placebo. Bone mineral density (BMD) at lumbar spine and hip was measured at baseline and after 1 year. Urinary - desoxypyridinoline cross-links (DPD) and plasma levels of tartrate resistant acid phosphatase (TRAP), C-terminal cross-links of collagen I (CTx), pro-collagen type I N-terminal peptide (PINP) and osteocalcin (OC) were measured after 0, 4, 8 and 12 months.Results: B-vitamin supplementation significantly reduced HCY (0 vs. 12 months: 13.6 4.8 vs. 8.9 2.4 mu mol/L). Placebo treatment had no effect on HCY (0 vs. 12 months: 12.0 +/- 3.4 vs. 12.7 +/- 3.9 [mu mol/L). BIVID, TRAP, CTx, OC and PINP did not change throughout the study in both groups. Vitamin treatment decreased urinary DPD by -13% (p15 mu Lmol/L, n =8), B-vitamin treatment tended to increase BMD at the lumbar spine, with a t-score from -2.7 to -1.7, and to decrease OC and PINP by approximately 50%.Conclusions: B-vitamin supplementation had no consistent effects on bone turnover or BMD. However, the situation may be different in patients with hyperhomocysteinemia.