Access to CF3-Containing Cyclopentaquinolinone Derivatives from Indolyl-ynones via Silver-Catalyzed One-pot Reaction
Access to CF3-Containing Cyclopentaquinolinone Derivatives from Indolyl-ynones via Silver-Catalyzed One-pot Reaction
复制标题
通过银催化一锅反应从吲哚酮制备含 CF3 的环五喹啉酮衍生物
DOI：
10.1002/adsc.201801482
复制
发表时间：
2019-02-19
影响因子：
5.4
通讯作者：
Liu, Yangping
中科院分区：
文献类型：
--
作者：
Han, Guifang;Xue, Li;Liu, Yangping
一种意外的银（I）催化的取代吲哚基 - 炔酮与Togni试剂之间的级联反应已被披露，该反应涉及多个过程，包括吲哚去芳构化、扩环、三氟甲基化和脱氢。这种一锅法反应可用于方便地以中等至良好的产率获得多种含CF₃的多取代环戊并喹啉酮骨架。
An unexpected Ag(I)-catalyzed cascade reaction between substituted indolyl-ynone and Togni's reagent has been disclosed in which multiple processes occur including indole dearomatization, ring expansion, trifluoro-methylation and dehydrogenation. This one-pot reaction can be used to conveniently access diverse CF3-containing multisubstituted cyclopentaquinolinone scaffolds in moderate to good yields.