Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition
Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition
复制标题
二异腈介导的活性氧积累导致细菌生长抑制
DOI：
10.1021/acs.jnatprod.0c00125
复制
发表时间：
2020-05-22
影响因子：
5.1
通讯作者：
He, Jing
中科院分区：
文献类型：
--
作者：
Zhu, Mengyi;Wang, Lijuan;He, Jing
硫解链霉菌（Streptomyces thioluteus）生物合成的二异腈铜螯合剂SF2768作为一种白垩载体，将胞外铜以络合形式转运到生产细胞中。结果表明，用SF2768处理8种细菌，包括枯草芽孢杆菌和鲍氏不动杆菌，导致与活性氧（ROS）水平增加相关的中度生长抑制。此外，SF 2768及其二异腈类似物被证明是有效的酪氨酸酶抑制剂。通过详细的光谱分析鉴定了三个新的类似物，SF 2768 I，K和L。
The diisonitrile copper chelator SF2768 biosynthesized by Streptomyces thioluteus functions as a chalkophore that transports extracellular copper into producer cells in a complexed form. It was demonstrated that the treatment of eight bacteria, including Bacillus subtilis and Acinetobacter baumannii, with SF2768 led to a moderate growth inhibition which is associated with an increased level of reactive oxygen species (ROS). In addition, SF2768 and its diisonitrile analogues proved to be effective tyrosinase inhibitors. Three new analogues, SF2768 I, K, and L, were identified by detailed spectroscopic analysis.