The Endocannabinoid System and Heart Disease: The Role of Cannabinoid Receptor Type 2.
The Endocannabinoid System and Heart Disease: The Role of Cannabinoid Receptor Type 2.
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DOI：
10.2174/1871529x18666180206161457
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Thewke DP
中科院分区：
文献类型：
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作者：
Fulmer ML;Thewke DP
几十年的研究已经为内源性大麻素系统在人类健康和疾病中的作用提供了证据。这个多功能系统由两种受体（CB1和CB2）、它们的内源性配体（内源性大麻素）和代谢酶组成，与从神经系统疾病到癌症等多种疾病状态有关。CB2因其有益的免疫调节作用而受到广泛关注，这种作用可以通过CB1获得而不引起精神药物作用。最近的研究揭示了CB2在心血管疾病中的保护作用，目前在西方国家，心血管疾病每年夺走的生命比任何其他疾病或损伤都要多。通过使用CB2敲除小鼠和CB2选择性配体，获得了CB2信号传导如何影响动脉粥样硬化和缺血的知识，为基础科学和转化临床研究提供了重要的跳板。在这里，我们总结了目前对内源性大麻素系统在人类病理中的理解，并对其在心血管疾病中的功能的临床前研究结果进行了回顾，特别强调了可能的以cb2为目标的治疗干预措施来缓解动脉粥样硬化。
Decades of research has provided evidence for the role of the endocannabinoid system in human health and disease. This versatile system, consisting of two receptors (CB1 and CB2), their endogenous ligands (endocannabinoids), and metabolic enzymes has been implicated in a wide variety of disease states, ranging from neurological disorders to cancer. CB2 has gained much interest for its beneficial immunomodulatory role that can be obtained without eliciting psychotropic effects through CB1. Recent studies have shed light on a protective role of CB2 in cardiovascular disease, an ailment which currently takes more lives each year in Western countries than any other disease or injury. By use of CB2 knockout mice and CB2-selective ligands, knowledge of how CB2 signaling affects atherosclerosis and ischemia has been acquired, providing a major stepping stone between basic science and translational clinical research. Here, we summarize the current understanding of the endocannabinoid system in human pathologies and provide a review of the results from preclinical studies examining its function in cardiovascular disease, with a particular emphasis on possible CB2-targeted therapeutic interventions to alleviate atherosclerosis.