Insulating behavior of lambda-DNA on the micron scale.
Insulating behavior of lambda-DNA on the micron scale.
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DOI：
10.1103/physrevlett.89.198102
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发表时间：
2002-05
影响因子：
8.6
通讯作者：
Yaojun Zhang;R. H. Austin;Jessica J. Kraeft;E. C. Cox;N. P. Ong
中科院分区：
文献类型：
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作者：
Yaojun Zhang;R. H. Austin;Jessica J. Kraeft;E. C. Cox;N. P. Ong
我们研究了DNA共价键合在Au电极上的导电性。使用DNA聚合酶将巯基修饰的dTTP掺入噬菌体DNA的“粘性”末端。对这种分子的双探针测量提供了在高达20 V的偏置电位下电阻率rho>10（6）Ω cm的硬下限，这与最近声称的中到高电导率相冲突。通过直接成像，我们证明了测量后分子的存在。我们强调在这些测量中消除盐残留的重要性。
We have investigated the electrical conductivity of lambda-DNA using DNA covalently bonded to Au electrodes. Thiol-modified dTTP was incorporated into the "sticky" ends of bacteriophage lambda-DNA using DNA polymerase. Two-probe measurements on such molecules provide a hard lower bound for the resistivity rho>10(6)Omega cm at bias potentials up to 20 V, in conflict with recent claims of moderate to high conductivity. By direct imaging, we show that the molecules are present after the measurements. We stress the importance of eliminating salt residues in these measurements.