Enantioenriched Synthesis of C1-Symmetric BINOLs: Iron-Catalyzed Cross-Coupling of 2-Naphthols and Some Mechanistic Insight
Enantioenriched Synthesis of C1-Symmetric BINOLs: Iron-Catalyzed Cross-Coupling of 2-Naphthols and Some Mechanistic Insight
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DOI：
10.1021/ja105442m
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发表时间：
2010-10-06
影响因子：
15
通讯作者：
Katsuki, Tsutomu
中科院分区：
文献类型：
--
作者：
Egami, Hiromichi;Matsumoto, Kenji;Katsuki, Tsutomu
以铁（salan）配合物为催化剂，实现了2-萘酚的高对映选择性、宽底物范围的有氧氧化偶联反应。产物的对映体过量范围为87 - 95%。在相同的反应条件下，交叉偶联反应的范围与同偶联反应的范围不同。
Highly enantioselective aerobic oxidative cross-coupling of 2-naphthols with broad substrate scope was achieved using an iron(salan) complex as the catalyst. Enantiomeric excesses of the products ranged from 87 to 95%. The scope of the cross-coupling reaction was found to be different from that of the homocoupling reaction under the same reaction conditions.