Mechanisms of scaling in pattern formation
Mechanisms of scaling in pattern formation
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DOI：
10.1242/dev.100511
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发表时间：
2013-12
期刊：
影响因子：
4.6
通讯作者：
David M. Umulis;H. Othmer
中科院分区：
文献类型：
--
作者：
David M. Umulis;H. Othmer
许多生物体及其组成组织和器官在大小上差异很大，但在形态上差异很小;它们似乎是一个共同模板或模式的缩放版本。这种缩放涉及调整基因表达空间模式的内在尺度，这些空间模式是在发育过程中建立的，以适应系统的大小。确定在发育过程中在组织，器官和生物体水平上调节模式缩放的机制是生物学中的一个长期挑战，但最近的分子水平数据和数学建模揭示了几个系统中的缩放机制，包括果蝇和非洲爪蟾。在这里，我们调查的基本原则，需要了解的机制，可以产生规模不变性的空间格局的形成，并讨论系统的例子，规模在发展过程中。
Many organisms and their constituent tissues and organs vary substantially in size but differ little in morphology; they appear to be scaled versions of a common template or pattern. Such scaling involves adjusting the intrinsic scale of spatial patterns of gene expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light on scaling mechanisms in several systems, including Drosophila and Xenopus. Here, we investigate the underlying principles needed for understanding the mechanisms that can produce scale invariance in spatial pattern formation and discuss examples of systems that scale during development.