Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids.
Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids.
复制标题
肌肉对运动的适应。
DOI：
--
复制
发表时间：
1971
影响因子：
15.9
通讯作者：
J. Holloszy
中科院分区：
文献类型：
--
作者：
P. Molé;L. B. Oscai;J. Holloszy
腓肠肌和四头肌肌肉氧化棕榈酸，油酸，亚油酸，棕榈酰辅酶A和棕榈酰肉碱的能力增加了一倍，在大鼠进行跑步机运行的程序。棕榈酸氧化率的整个匀浆，或线粒体部分，腿部肌肉的两倍大，每克湿重的肌肉在训练的久坐不动的动物在一个广泛的范围内（0.125-1.5毫米）的棕榈酸浓度。肉毒碱棕榈酰转移酶，棕榈酰CoA脱氢酶，线粒体ATP依赖性棕榈酰CoA合成酶的活性水平每克肌肉加倍腓肠肌和四头肌肌肉响应于运行程序。这些肌肉线粒体部分的蛋白质含量增加了约60%。
The capacity of gastrocnemius and quadriceps muscles to oxidize palmitate, oleate, linoleate, palmityl CoA, and palmityl carnitine doubled in rats subjected to a program of treadmill running. The rate of palmitate oxdation by whole homogenates of, or the mitochondrial fraction from, leg muscles was twice as great per gram wet weight of muscle in the trained as in the sedentary animals over a wide range (0.125-1.5 mM) of palmitate concentrations. The levels of activity of carnitine palmityltransferase, palmityl CoA dehydrogenase, and mitochondrial ATP-dependent palmityl CoA synthetase expressed per gram of muscle doubled in gastrocnemius and quadriceps muscles in response to the running program. The protein content of the mitochondrial fraction from these muscles was increased approximately 60%.