Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma
Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma
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DOI：
10.1016/s0009-9120(99)00022-3
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发表时间：
1999-07-01
影响因子：
2.8
通讯作者：
Burçak, G
中科院分区：
文献类型：
--
作者：
Seven, A;Civelek, S;Burçak, G
目的：在这项研究中，通过硫代巴比妥酸反应物质和红细胞抗氧化状态标志物（即铜锌超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽和维生素 C 和 E 的血浆水平）评估血浆脂质过氧化情况，研究对象为 20 名喉癌患者和 15 名健康对照者。设计和方法：观察到，在喉癌组与健康对照组的比较。 I+II期和III期癌症患者均观察到硫代巴比妥酸反应物质显着高于对照组。对照组与 I+II 期和 III 期癌症患者之间血浆维生素 E 水平存在显着差异（分别为 p < 0.01、0.05 > p > 0.02）。结果：我们的研究结果表明，喉癌患者的脂肪氧化损伤增加，但内源性抗氧化成分 GSH、GSH Pr 和 CuZn SOD 没有变化。版权所有 (C) 1999 加拿大临床化学家协会。
Objectives: In this study, plasma lipid peroxidation as assessed by thiobarbituric acid reactive substances and erythrocyte antioxidant status markers namely CuZn superoxide dismutase, glutathione peroxidase, glutathione and plasma levels of vitamin C and E were investigated in 20 patients with larygneal carcinoma and 15 healthy controls.Design and Methods: Lipid peroxidation was observed to be significantly higher (0.01 > p > 0.001) in the larynx carcinoma group in comparison to the healthy controls. Both stage I+II and stage III carcinoma patients were observed to have significantly higher thiobarbituric acid reactive substances than the control group. A significant difference was found in plasma vitamin E level between the control group and stage I+II and stage III carcinoma patients (p < 0.01, 0.05 > p > 0.02, respectively).Results: Our findings reveal the presence of increased lipooxidative damage in laryngeal carcinoma patients, but no change with respect to the endogenous antioxidant components-GSH, GSH Pr, and CuZn SOD. Copyright (C) 1999 The Canadian Society of Clinical Chemists.