Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers:: a comparison with gene negative at risk subjects
Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers:: a comparison with gene negative at risk subjects
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DOI：
10.1034/j.1600-0447.2002.0o456.x
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发表时间：
2002-03-01
影响因子：
6.7
通讯作者：
Hodges, JR
中科院分区：
文献类型：
--
作者：
Berrios, GE;Wagle, AC;Hodges, JR
目的：两个高危人群[亨廷顿氏病（HD），基因携带者和非携带者]的精神概况进行了比较，通过一个计算机化的电池和结构化interview.Method：为了避免混淆，只有受试者谁是免费的神经和认知功能障碍（神经系统无症状）被列入研究。为了避免评估偏差，所有的科目都看到之前的基因testings.Results：基因携带者有显着较差的识别记忆和得分较高的措施，易怒比对照组。这些群体在精神症状的因素结构方面也有所不同。没有一个合格的受试者在评估时的精神病诊断。结论：各组不同，他们的档案的精神症状。据推测，这些差异是表现或不同的机制，即认知缺陷与遗传因素和神经质投诉更多地是在一个不安的家庭背景中长大。讨论了有关仪器灵敏度、选择偏倚和连续评估的优点等问题。
Objective: Psychiatric profiles of two at-risk groups [Huntington's disease (HD), gene carriers and non-carriers] were compared by means of a computerized battery and a structured interview.Method: To avoid confounding, only subjects who were free from neurological and cognitive deficits (neurologically asymptomatic) were included in the study. To avoid evaluation biases, all subjects were seen before the genetic testing was undertaken.Results: Gene carriers had significantly worse recognition memory and scored higher in measures of irritability than controls. The groups also differed in terms of the factor structure of their psychiatric symptoms. None of the subjects qualified for a psychiatric diagnosis at the time of assessment.Conclusion: The groups differed with respect to their profile of psychiatric symptoms. It is hypothesized that these differences are the expression or different mechanisms, i.e. that cognitive deficits relate more to genetic factors and neurotic complaints more to being brought up in a disturbed family background. Issues concerning instrument sensitivity, selection bias and the advantage of seriatim assessments are discussed.