Metallothionein in plasma and urine of cadmium workers.
Metallothionein in plasma and urine of cadmium workers.
复制标题
镉工人血浆和尿液中的金属硫蛋白。
DOI：
10.1016/0013-9351(82)90167-0
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发表时间：
1982
影响因子：
8.3
通讯作者：
Chang,CC
中科院分区：
文献类型：
--
作者：
Nordberg,GF;Garvey,JS;Chang,CC
对瑞典一家生产镉电池的工厂31名工人的血浆和尿样中金属硫蛋白(MT)和β-2-微球蛋白(BM)浓度进行了测定。血浆金属硫蛋白浓度为2~11 ng/g，尿金属硫蛋白浓度为2~15 5 ng/g，尿BM浓度>5 0 0μg/L者尿MT中位数显著高于尿BM<5 0 0μg/L者。然而，在个别病例中，可能会出现尿BM的显著增加，而不会出现尿MT的任何增加。指出了血浆中MT浓度降低与CD-MT向肾皮质转运有关的可能意义。
Metallothionein (MT) and β-2-microglobulin (BM) concentrations were determined in samples of plasma and urine from 31 workers in a Swedish factory manufacturing cadmium batteries. Concentrations of metallothionein in plasma varied from 2 to 11 ng/g and in urine from 2 to 155 ng/g. In workers with urinary BM concentrations above 500 μg/liter the median value of MT in urine was statistically significantly higher than that in workers with urinary BM concentrations lower than 500 μg/liter. In individual cases, however, a considerable increase in urinary BM may occur without any increase in urinary MT. The possible significance of of reased MT concentrations in plasma, as seen in some of the workers in the present study, in relation to transport of Cd-MT to the renal cortex is pointed out.