Outcomes in Severe Hyponatremia Treated With and Without Desmopressin
Outcomes in Severe Hyponatremia Treated With and Without Desmopressin
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DOI：
10.1016/j.amjmed.2017.09.048
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发表时间：
2018-03-01
影响因子：
5.9
通讯作者：
Cavalcanti, Rodrigo B.
中科院分区：
文献类型：
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作者：
MacMillan, Thomas E.;Cavalcanti, Rodrigo B.
背景：严重低钠血症患者的血钠纠正过度与渗透性脱髓鞘综合征有关。去氨加压素(DDAVP)可预防低钠血症患者的血钠过度纠正。本研究的目的是根据DDAVP的用法比较低钠血症的预后。方法：这是一项回顾性观察研究，包括2004年至2014年在加拿大多伦多两家学术医院入院的所有低钠血症患者(血钠浓度123mEq/L)。主要结果是安全的钠矫正(
BACKGROUND: Overcorrection of plasma sodium in severe hyponatremia is associated with osmotic demyelination syndrome. Desmopressin (DDAVP) can prevent overcorrection of plasma sodium in hyponatremia. The objective of this study was to compare outcomes in hyponatremia according to DDAVP usage.METHODS: This was a retrospective observational study including all admissions to internal medicine with hyponatremia (plasma sodium concentration < 123 mEq/L) from 2004 to 2014 at 2 academic hospitals in Toronto, Canada. The primary outcome was safe sodium correction (