Targeting Inflammation to Prevent Bronchopulmonary Dysplasia: Can New Insights Be Translated Into Therapies?
Targeting Inflammation to Prevent Bronchopulmonary Dysplasia: Can New Insights Be Translated Into Therapies?
复制标题
DOI：
10.1542/peds.2010-3875
复制
发表时间：
2011-07-01
期刊：
影响因子：
8
通讯作者：
Kirpalani, Haresh
中科院分区：
文献类型：
--
作者：
Wright, Clyde J.;Kirpalani, Haresh
支气管肺发育不良（BPD）经常使早产复杂化，并导致严重的长期发病率。不幸的是，目前已知很少有疗法可以有效预防或治疗 BPD。正在进行的研究一直专注于限制早产肺部炎症的潜在疗法。在这篇综述中，我们重点介绍了最近的实验室和临床研究，旨在了解炎症在 BPD 发病机制中的作用。我们还严格评估当前使用的疗法和该领域有前途的发展。儿科2011; 128：111-126
Bronchopulmonary dysplasia (BPD) frequently complicates preterm birth and leads to significant long-term morbidity. Unfortunately, few therapies are known to effectively prevent or treat BPD. Ongoing research has been focusing on potential therapies to limit inflammation in the preterm lung. In this review we highlight recent bench and clinical research aimed at understanding the role of inflammation in the pathogenesis of BPD. We also critically assess currently used therapies and promising developments in the field. Pediatrics 2011; 128: 111-126