Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose.
Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose.
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介导葡萄糖抑制下丘脑神经元的代谢途径。
DOI：
10.2337/diabetes.53.1.67
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发表时间：
2004
期刊：
影响因子：
7.7
通讯作者：
C. Mobbs
中科院分区：
文献类型：
--
作者：
Xue;L. Kow;D. Pfaff;C. Mobbs
Neurons in the ventromedial hypothalamus mediate some counterregulatory responses to hypoglycemia and 2-deoxyglucose, but the mechanisms that mediate these responses to glucose are unclear. In the present study, ventromedial hypothalamus neurons were identified on the basis of their inhibition by the transition from 5 to 20 mmol/l glucose. Tolbutamide, which activates glucose-stimulated neurons, failed to inhibit or activate glucose-inhibited neurons. Inhibitors of glucose transport and glycolysis, in particular by the glucokinase inhibitor glucosamine, blocked the effect of glucose on glucose-inhibited neurons. Furthermore, the glucose-inhibited neurons were activated by 2-deoxyglucose, which also activates counterregulatory responses. Conversely, glucose-inhibited neurons were inhibited by glycolytic metabolites, including lactate, but not by pyruvate. These data indicate that hypoglycemia induces electrical activity in glucose-inhibited neurons by attenuating glycolysis in those neurons. Thus, counterregulatory failure could be due to relatively enhanced glycolysis in glucose-stimulated neurons during hypoglycemia and attenuation of glycolysis in glucose-inhibited neurons might reverse counterregulatory failure.
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影响因子：
7.7
作者：
Song, ZT;Levin, BE;Routh, VH
通讯作者：
Routh, VH
DOI：
10.1016/0026-0495(89)90158-3
发表时间：
1989
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Meglasson,MD;Nelson,J;Nelson,D;Erecinska,M
通讯作者：
Erecinska,M
影响因子：
16.6
作者：
C. B. Newgard;J. McGarry
通讯作者：
C. B. Newgard;J. McGarry
DOI：
10.1073/pnas.90.5.1781
发表时间：
1993-03-01
影响因子：
11.1
作者：
GERMAN, MS
通讯作者：
GERMAN, MS
DOI：
10.1016/s0021-9258(17)37629-9
发表时间：
1994-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
N. Sekine;V. Cirulli;R. Regazzi;L. Brown;E. Giné;J. Tamarit-Rodriguez;Milena Girotti;S. Marie;M. MacDonald;C. Wollheim;G. Rutter;G. Rutter
通讯作者：
N. Sekine;V. Cirulli;R. Regazzi;L. Brown;E. Giné;J. Tamarit-Rodriguez;Milena Girotti;S. Marie;M. MacDonald;C. Wollheim;G. Rutter;G. Rutter