HISTIDINE-RICH PROTEIN IN DEVELOPING RAT EPIDERMIS
HISTIDINE-RICH PROTEIN IN DEVELOPING RAT EPIDERMIS
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DOI：
10.1016/0012-1606(81)90283-9
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发表时间：
1981-01-01
影响因子：
2.7
通讯作者：
EPSTEIN, WL
中科院分区：
文献类型：
--
作者：
FUKUYAMA, K;MARSHBURN, I;EPSTEIN, WL
用组织化学和免疫组织化学方法研究了发育期大鼠表皮中富组氨酸蛋白的定位。与保利反应的结果是相同的，具有两种不同分子量的富含组氨酸的蛋白质的抗血清，都从新生大鼠表皮纯化。在胎儿颗粒形成之前，富含组氨酸的蛋白在整个表皮中弥漫检测。胚胎颗粒和透明角质颗粒均显示富含组氨酸的蛋白质，但胚胎颗粒细胞仍位于体表，而透明角质颗粒细胞则分化为皮质细胞。这些结果表明，富含组氨酸的蛋白质可能是化学异质性的，其生物学功能可能不仅限于在皮质细胞中形成基质。
The localization of histidine-rich protein in the epidermis of developing rat was studied histochemically and immunohistochemically. The findings with the Pauly reaction were identical to those with antisera to histidine-rich proteins having two different molecular weights, both purified from newborn rat epidermis. Histidine-rich protein was detected diffusely throughout the epidermis before fetal granules were formed. Both fetal granules and keratohyalin granules showed concentration of histidine-rich protein(s), but the cells with fetal granules remained at the superficial layer of the body, whereas cells with keratohyalin granules differentiated to form cornified cells. The findings suggest that histidine-rich protein may be chemically heterogeneous and its biological function may not be limited to formation of the matrix in cornified cells.