Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum
Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum
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DOI：
10.1016/j.phytol.2012.08.007
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发表时间：
2012-12-01
影响因子：
1.7
通讯作者：
Ye, Wen-Cai
中科院分区：
文献类型：
--
作者：
Chen, Li-Li;Huang, Xiao-Jun;Ye, Wen-Cai
从何首乌（Polygonummultiflorum）中分离得到一个新的黄酮二苯乙烯苷类化合物Polygonflavanol A（1）和5个已知的二苯乙烯苷类化合物Polygonflavanol A（2-6）。根据广泛的光谱分析和化学证据，阐明了结构。通过CD分析进一步确定了1的绝对构型。大部分化合物均能抑制脂多糖（LPS）诱导的RAW264.7细胞分泌一氧化氮（NO），且呈剂量依赖性。其中，化合物2显示出最高的抑制活性。(c)2012欧洲植物化学学会。Elsevier B. V.出版，保留所有权利。
Polygonflavanol A (1), a novel flavonostilbene glycoside with an unusual coupling pattern, together with five known stilbene glycosides (2-6), was isolated from the roots of Polygonum multiflorum. The structures were elucidated on the basis of extensive spectroscopic analysis and chemical evidence. The absolute configuration of 1 was further determined by CD analysis. Most of the compounds could inhibit nitric oxide (NO) secretion of RAW264.7 cells in respond to lipopolysaccharide (LPS) in a dose dependent manner. Among them, compound 2 displayed the highest inhibitory activity. (c) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.