EFFECT OF PENICILLIN PROPHYLAXIS ON NASOPHARYNGEAL COLONIZATION WITH STREPTOCOCCUS-PNEUMONIAE IN CHILDREN WITH SICKLE-CELL-ANEMIA
EFFECT OF PENICILLIN PROPHYLAXIS ON NASOPHARYNGEAL COLONIZATION WITH STREPTOCOCCUS-PNEUMONIAE IN CHILDREN WITH SICKLE-CELL-ANEMIA
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DOI：
10.1016/s0022-3476(84)80582-x
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发表时间：
1984-01-01
影响因子：
5.1
通讯作者：
BUCHANAN, GR
中科院分区：
文献类型：
--
作者：
ANGLIN, DL;SIEGEL, JD;BUCHANAN, GR
研究了34例接受青霉素预防治疗的镰状细胞性贫血患者（6岁至5岁）和63例年龄和种族匹配的对照患者的鼻咽部定植肺炎球菌。镰状细胞性贫血患者的初始肺炎球菌鼻咽培养阳性率低于对照组（14.5 vs 34.4%, P = 0.03），并且在11月至3月呼吸道疾病季节的携带率显著降低（8.7 vs 40.5%, P = 0.005）。青霉素预防并未导致耐青霉素肺炎球菌的出现或b型流感嗜血杆菌携带率的增加。提出了青霉素预防的作用机制；为该方案的相对安全性提供了一些证据。
Nasopharyngeal colonization with pneumococci was studied in 34 patients with sickle cell anemia (aged 6 mo.-5 yr) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5 vs. 34.4%, P = 0.03) and significantly lower carriage rates during the respiratory illness season of Nov.- March (8.7 vs 40.5%, P = 0.005). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of Haemophilus influenzae type b. A mechanism of action for penicillin prophylaxis is suggested; some evidence for the relative safety of this regimen is provided.